Hormesis and homeopathy: The artificial twins
Hormesis is any process in a cell or organism that exhibits a biphasic response to exposure to increasing amounts of a substance or condition. Within the hormetic zone, there is generally a favorable biological response It has been claimed that this relationship, characterized by positive effects at an intermediate dose of . Keywords. Hormesis, Homeopathy, High Dilutions, Similarity Principle, Ultra-low Doses. Introduction concept, with a simple definition, that is thus useful for describing a describing the relationship between living things (cells, tissues, entire. The significant connection between homeopathy and hormesis is stressed out, dichotomy because of the different conceptual roots defining the operational.
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Hormesis and Homeopathy: Toward a New Self-Consciousness
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Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase-mediated signaling via reactive oxygen species elevation. Evidence of an epigenetic modification in cell-cycle arrest caused by the use of ultra-highly-diluted Gonolobus condurango extract. Transcriptome profiling of wheat seedlings following treatment with ultrahigh diluted arsenic trioxide. Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro.
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Hormesis and Homeopathy: Toward a New Self-Consciousness
Exploring the effects of homeopathic Apis mellifica preparations on human gene expression profiles. Dei A, Bernardini S. In the widely used Linear No Threshold LNT theory used by regulatory bodies, the expected cancer deaths in this population would have been with 70 caused by the extra ionizing radiation with the remainder caused by natural background radiation.
However the observed cancer rate was quite low at 7 cancer deaths when would be predicted by the LNT theory. Ionizing radiation hormesis appears to be at work. Described by Professor Charles L. The results suggest that prolonged low dose-rate radiation exposure appeared to increase risks of developing certain cancers in specific subgroups of this population in Taiwan.
Update on hormesis and its relation to homeopathy.
Breast cancer exhibited a marginally significant dose response HR mGy 1. The results further strengthen the association between protracted low-dose radiation and cancer risks, especially for breast cancers and leukemia, in this unique cohort population.
Thick lead shielding around a chemical dose experiment to rule out the effects of ionizing radiation is built and rigorously controlled for in the laboratory, and certainly not the field. Likewise the same applies for ionizing radiation studies. Ionizing radiation is released when an unstable particle releases radiation, creating two new substances and energy in the form of an electromagnetic wave.
The resulting materials are then free to interact with any environmental elements, and the energy released can also be used as a catalyst in further ionizing radiation interactions. For example cell death is seen as a 'bad' effect but if it removes a potentially carcinogenic cell from the population of cells in a tissue it could prevent cancer starting and could be seen as 'good'. At least one peer-reviewed article accepts the idea, claiming that over substances show a U-shaped dose-response relationship.
Calaberese and Baldwin wrote: This theory is called radiation hormesis. For policy making purposes, the commonly accepted model of dose response in radiobiology is the linear no-threshold model LNTwhich assumes a strictly linear dependence between the risk of radiation-induced adverse health effects and radiation dose. A report commissioned by the French National Academy concluded that there is sufficient evidence for hormesis occurring at low doses and that LNT should be reconsidered as the methodology used to estimate risks from low level sources of radiation, like deep geological repositories for nuclear waste.
Hormesis - Wikipedia
In the linear model, the assumption is that there is no dosage that has no risk of causing cancer. While this linear approach remains the default[ citation needed ], with sufficient mechanistic evidence suggesting a non-linear dose-response, EPA allows for the derivation of a threshold dose also known as reference dose below which it is assumed that there is no risk for cancer. Similarly, low doses of the phthalate DEHP cause increased allergic responses to allergenswhile higher doses have no effect.What Is Homeopathy And Is It Real Science?
In all likelihood, recognizing that low dose effects can't be predicted from high dose experiments would force a strengthening of public health standards, not their weakening, as hormesis proponents would argue.
Any policy change ought to consider hormesis first as a public health issue versus an industrial regulatory issue.